CLADRIBINE ALTERS IMMUNE CELL SURFACE MOLECULES FOR ADHESION AND COSTIMULATION: FURTHER INSIGHTS TO THE MODE OF ACTION IN MULTIPLE SCLEROSIS

Cladribine Alters Immune Cell Surface Molecules for Adhesion and Costimulation: Further Insights to the Mode of Action in Multiple Sclerosis

Cladribine (CLAD) is a deoxyadenosine analogue prodrug which is given in multiple sclerosis (MS) as two short oral treatment courses 12 months apart.Reconstitution of adaptive immune function following selective immune cell depletion is the presumed mode of action.In this exploratory study, we investigated the impact of CLAD Lacrosse - Shoes tablet

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Coccygodynia

The coccyx, the last segment of the spine, joins the sacrum at the base.It has three to five vertebrae, which are typically fused.In front of the sacrococcygeal junction is the ganglion impar, the only unpaired autonomic ganglion.The two sympathetic chains come to a close there.The impar ganglion is traversed by sympathetic nerves carrying pain fib

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